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KMID : 0378019720150070099
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New Medical Journal
1972 Volume.15 No. 7 p.99 ~ p.110
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The Production of Human Grouping Sera on a Hospital Scale
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김신걸
김태순/황기석/문세광/임경일/김원자
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Abstract
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The efficacy of producing human anti-A and anti-B grouping sera utilizing simple hospital facilities was put into test in compliance with general increase in demand airising from the Blood Donation Movement and the increased use of blood transfusions.
The subcutaneous injections of the Group Specific Substance was employed to induce the rise of antiA and anti-B agglutinins in the selected donors.
After the confirmation of the acceptable, high titer, the prepared sera was compared with the Hyland Typing sera through routine blood typing. The subsequently lyophilized sera was stored in room temperature for 7 months after which the potency was again compared with the Hyland product.
The results on 794 cases show (1) Average confirmation time for agglutination, 4.3 seconds for the Army product, 3.6 seconds for Hyland (2) Blood group distribution of A 32.3%, B 33.7% AB 9.8%, o 24.5% (3) That the majority of the anti-A and anti-B agglutinin titers were running between 1;32 and 1;64 (4) That only few cases were found to contain the titer higher than 1;256 which is the official standard unit for the typing sera, (5) That the group specific substance raised the agglutin titer from 1;32 to 1;512 in two weeks time.
The methods, the needs, the economy are discussed together with photographic presentation.
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KEYWORD
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